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Genesis Genomics

Skin Cancer / Sun Damage

     Recent Publications on Skin Cancer / Sun Damage (2002 -
     Present)  

  1. Ultraviolet radiation exposure accelerates the accumulation of the aging-dependent T414G mitochondrial DNA mutation in human skin. Aging Cell 2007, 6(4), 557-564.

  2.  Real-time PCR analysis of a 3895 bp mitochondrial DNA deletion in non-melanoma skin cancer and its use as a quantitative marker for sunlight exposure in human skin. British Journal of Cancer 2006, 94, 1887-1893.

  3. The incidence of both tandem duplications and the common deletion in mitochondrial DNA from three distinct categories of sun-exposed human skin and in prolonged culture of fibroblasts. Journal of Investigative Dermatology 2006, 126, 408-415.

  4. The role of mitochondria in aging and carcinogenesis. Clinical and Experimental Dermatology 2006, 31(4), 548-52.

  5. Towards a `free radical theory of graying´: Melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB Journal 2006, 20(9), 1567-9.

  6. The anti-psoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondria. FASEB Journal 2005, 19(8), 1012-4.

  7. Using mitochondrial DNA as a biosensor of early cancer development.  British Journal of Cancer 2005, 93(3), 271-272.

  8. Implications of using the ND1 gene as a control region for real-time PCR analysis of mitochondrial DNA deletions in human skin. Journal of Investigative Dermatology 2004, 122, 1518-1522.

  9. The use of a 3895bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin.  Journal of Investigative Dermatology 2004, 123, 1020-1024.

  10. Current pitfalls in the measurement of the 4977bp mitochondrial DNA common deletion in human skin. Journal of Investigative Dermatology 2003, 120, 981-982.

  11. Mitochondrial DNA damage in non-melanoma skin cancer. British Journal of Cancer 2003, 88, 90-95.



 

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